{
 "twelveMonth": [
  {
   "label": "Testosterone",
   "measure": "testosterone",
   "order": 1,
   "estimate": -95.6,
   "ciLow": -97.8,
   "ciHigh": -48.8,
   "intervalType": "range",
   "unit": "% change after about 12 months",
   "n": 12,
   "method": "Median of the percentage changes in the included study groups; the range is the lowest and highest study group."
  },
  {
   "label": "Hemoglobin (red blood cells)",
   "measure": "hemoglobin",
   "order": 2,
   "estimate": -7,
   "ciLow": -14,
   "ciHigh": -4.6,
   "intervalType": "range",
   "unit": "% change after about 12 months",
   "n": 5,
   "method": "Median of the percentage changes in the included study groups; the range is the lowest and highest study group."
  },
  {
   "label": "Muscle size",
   "measure": "muscleArea",
   "order": 3,
   "estimate": -6.4,
   "ciLow": -9.5,
   "ciHigh": -1.5,
   "intervalType": "range",
   "unit": "% change after about 12 months",
   "n": 4,
   "method": "Median of the percentage changes in the included study groups; the range is the lowest and highest study group."
  },
  {
   "label": "Lean body mass",
   "measure": "leanMass",
   "order": 4,
   "estimate": -4,
   "ciLow": -5.4,
   "ciHigh": -0.8,
   "intervalType": "range",
   "unit": "% change after about 12 months",
   "n": 8,
   "method": "Median of the percentage changes in the included study groups; the range is the lowest and highest study group."
  },
  {
   "label": "Strength",
   "measure": "strength",
   "order": 5,
   "estimate": 0.5,
   "ciLow": -7.1,
   "ciHigh": 2,
   "intervalType": "range",
   "unit": "% change after about 12 months",
   "n": 5,
   "method": "Median of the percentage changes in the included study groups; the range is the lowest and highest study group."
  }
 ],
 "groupRows": [
  {
   "measure": "testosterone",
   "study": "Mueller et al (2011)",
   "group": null,
   "detail": "Serum testosterone",
   "n": 84,
   "months": "12",
   "pctChange": -95.6,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "testosterone",
   "study": "Wierckx et al (2014)",
   "group": "oral oestrogen",
   "detail": "Serum testosterone",
   "n": 40,
   "months": "12",
   "pctChange": -97.8,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "testosterone",
   "study": "Wierckx et al (2014)",
   "group": "transdermal oestrogen",
   "detail": "Serum testosterone",
   "n": 12,
   "months": "12",
   "pctChange": -97.5,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "testosterone",
   "study": "Gava et al (2016)",
   "group": "cyproterone acetate",
   "detail": "Serum testosterone",
   "n": 20,
   "months": "12",
   "pctChange": -95.7,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "testosterone",
   "study": "Gava et al (2016)",
   "group": "leuprolide acetate",
   "detail": "Serum testosterone",
   "n": 20,
   "months": "12",
   "pctChange": -96.8,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "testosterone",
   "study": "Auer et al (2016)",
   "group": null,
   "detail": "Serum testosterone",
   "n": 20,
   "months": "12",
   "pctChange": -89.1,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "testosterone",
   "study": "Haraldsen et al (2007)",
   "group": null,
   "detail": "Serum testosterone",
   "n": 12,
   "months": "12",
   "pctChange": -48.8,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "testosterone",
   "study": "Van Caenegem et al (2015)",
   "group": null,
   "detail": "Serum testosterone",
   "n": 49,
   "months": "12",
   "pctChange": -97.4,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "testosterone",
   "study": "Elbers et al (1999)",
   "group": null,
   "detail": "Serum testosterone",
   "n": 20,
   "months": "12",
   "pctChange": -95.5,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "testosterone",
   "study": "Wiik et al (2020)",
   "group": null,
   "detail": "Serum testosterone",
   "n": 11,
   "months": "12",
   "pctChange": -97.2,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "testosterone",
   "study": "Scharff et al (2019)",
   "group": null,
   "detail": "Serum testosterone",
   "n": 249,
   "months": "12",
   "pctChange": -95.6,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "testosterone",
   "study": "Gooren and Bunck (2004)",
   "group": null,
   "detail": "Serum testosterone",
   "n": 19,
   "months": "12",
   "pctChange": -95.3,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "testosterone",
   "study": "Tack et al (2018)",
   "group": null,
   "detail": "Serum testosterone",
   "n": 21,
   "months": "12-31",
   "pctChange": -42.1,
   "included": false,
   "exclusionReason": "Adolescents; follow-up 12-31 months"
  },
  {
   "measure": "testosterone",
   "study": "Olson-Kennedy et al (2018)",
   "group": null,
   "detail": "Serum testosterone",
   "n": 23,
   "months": "12",
   "pctChange": -60.1,
   "included": false,
   "exclusionReason": "Youth cohort (adolescents and young adults)"
  },
  {
   "measure": "hemoglobin",
   "study": "Wierckx et al (2014)",
   "group": "oral oestrogen",
   "detail": "Hematocrit",
   "n": 40,
   "months": "12",
   "pctChange": -7,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "hemoglobin",
   "study": "Wierckx et al (2014)",
   "group": "transdermal oestrogen",
   "detail": "Hematocrit",
   "n": 12,
   "months": "12",
   "pctChange": -4.6,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "hemoglobin",
   "study": "Auer et al (2016)",
   "group": null,
   "detail": "Hematocrit",
   "n": 20,
   "months": "12",
   "pctChange": -5.5,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "hemoglobin",
   "study": "Gooren and Bunck (2004)",
   "group": null,
   "detail": "Hemoglobin",
   "n": 19,
   "months": "12",
   "pctChange": -14,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "hemoglobin",
   "study": "Wiik et al (2020)",
   "group": null,
   "detail": "Hemoglobin",
   "n": 10,
   "months": "12",
   "pctChange": -11.7,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "hemoglobin",
   "study": "Defreyne et al (2018)",
   "group": null,
   "detail": "Hematocrit",
   "n": 239,
   "months": "3",
   "pctChange": -8.9,
   "included": false,
   "exclusionReason": "Measured at 3 and 24 months; no 12-month value"
  },
  {
   "measure": "hemoglobin",
   "study": "Olson-Kennedy et al (2018)",
   "group": null,
   "detail": "Hemoglobin",
   "n": 23,
   "months": "12",
   "pctChange": -8.3,
   "included": false,
   "exclusionReason": "Youth cohort (adolescents and young adults)"
  },
  {
   "measure": "muscleArea",
   "study": "Elbers et al (1999)",
   "group": "thigh",
   "detail": "Muscle cross-sectional area",
   "n": 20,
   "months": "12",
   "pctChange": -9.5,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "muscleArea",
   "study": "Wiik et al (2020)",
   "group": "quadriceps",
   "detail": "Muscle cross-sectional area",
   "n": 11,
   "months": "12",
   "pctChange": -4.2,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "muscleArea",
   "study": "Van Caenegem et al (2015)",
   "group": "forearm",
   "detail": "Muscle cross-sectional area",
   "n": 49,
   "months": "12",
   "pctChange": -8.6,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "muscleArea",
   "study": "Van Caenegem et al (2015)",
   "group": "tibia (calf)",
   "detail": "Muscle cross-sectional area",
   "n": 49,
   "months": "12",
   "pctChange": -1.5,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "muscleArea",
   "study": "Tack et al (2018)",
   "group": "forearm",
   "detail": "Muscle cross-sectional area",
   "n": 21,
   "months": "12-31",
   "pctChange": -4.1,
   "included": false,
   "exclusionReason": "Adolescents; follow-up 12-31 months"
  },
  {
   "measure": "leanMass",
   "study": "Mueller et al (2011)",
   "group": null,
   "detail": "Total lean body mass",
   "n": 84,
   "months": "12",
   "pctChange": -4,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "leanMass",
   "study": "Wierckx et al (2014)",
   "group": "oral oestrogen",
   "detail": "Total lean body mass",
   "n": 40,
   "months": "12",
   "pctChange": -5.4,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "leanMass",
   "study": "Wierckx et al (2014)",
   "group": "transdermal oestrogen",
   "detail": "Total lean body mass",
   "n": 12,
   "months": "12",
   "pctChange": -4.6,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "leanMass",
   "study": "Gava et al (2016)",
   "group": "cyproterone acetate",
   "detail": "Total lean body mass",
   "n": 20,
   "months": "12",
   "pctChange": -3.5,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "leanMass",
   "study": "Gava et al (2016)",
   "group": "leuprolide acetate",
   "detail": "Total lean body mass",
   "n": 20,
   "months": "12",
   "pctChange": -0.8,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "leanMass",
   "study": "Klaver et al (2018)",
   "group": null,
   "detail": "Total lean body mass",
   "n": 179,
   "months": "12",
   "pctChange": -3,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "leanMass",
   "study": "Haraldsen et al (2007)",
   "group": null,
   "detail": "Total lean body mass",
   "n": 12,
   "months": "12",
   "pctChange": -4,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "leanMass",
   "study": "Van Caenegem et al (2015)",
   "group": null,
   "detail": "Total lean body mass",
   "n": 49,
   "months": "12",
   "pctChange": -4,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "leanMass",
   "study": "Auer et al (2018)",
   "group": null,
   "detail": "Total lean body mass",
   "n": 45,
   "months": "5-31",
   "pctChange": -3.4,
   "included": false,
   "exclusionReason": "Follow-up 5-31 months"
  },
  {
   "measure": "leanMass",
   "study": "Tack et al (2018)",
   "group": null,
   "detail": "Total lean body mass",
   "n": 21,
   "months": "12-31",
   "pctChange": -4.7,
   "included": false,
   "exclusionReason": "Adolescents; follow-up 12-31 months"
  },
  {
   "measure": "strength",
   "study": "Van Caenegem et al (2015)",
   "group": "hand grip",
   "detail": "Hand grip strength",
   "n": 49,
   "months": "12",
   "pctChange": -7.1,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "strength",
   "study": "Auer et al (2016)",
   "group": "hand grip",
   "detail": "Hand grip strength",
   "n": 20,
   "months": "12",
   "pctChange": 0.5,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "strength",
   "study": "Scharff et al (2019)",
   "group": "hand grip",
   "detail": "Hand grip strength",
   "n": 249,
   "months": "12",
   "pctChange": -4.3,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "strength",
   "study": "Wiik et al (2020)",
   "group": "knee extension",
   "detail": "Knee extension torque",
   "n": 11,
   "months": "12",
   "pctChange": 1.2,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "strength",
   "study": "Wiik et al (2020)",
   "group": "knee flexion",
   "detail": "Knee flexion torque",
   "n": 11,
   "months": "12",
   "pctChange": 2,
   "included": true,
   "exclusionReason": null
  },
  {
   "measure": "strength",
   "study": "Tack et al (2018)",
   "group": "hand grip",
   "detail": "Hand grip strength",
   "n": 21,
   "months": "12-31",
   "pctChange": 1.5,
   "included": false,
   "exclusionReason": "Adolescents; follow-up 12-31 months"
  }
 ],
 "runGap": [
  {
   "timeOnHormones": "Year 0 (before)",
   "estimate": 147,
   "ciLow": 121,
   "ciHigh": 173,
   "ciLevel": 0.95,
   "unit": "seconds faster than the average Air Force woman over 1.5 miles",
   "transWomenSeconds": 708,
   "averageWomanSeconds": 855,
   "speedAdvantagePct": 20.8,
   "method": "Roberts et al. (2021) Table 4 mean difference from the average Air Force woman under 30, sign reversed so faster is positive; 95% CI from the paper."
  },
  {
   "timeOnHormones": "Year 0-1",
   "estimate": 97,
   "ciLow": 70,
   "ciHigh": 124,
   "ciLevel": 0.95,
   "unit": "seconds faster than the average Air Force woman over 1.5 miles",
   "transWomenSeconds": 758,
   "averageWomanSeconds": 855,
   "speedAdvantagePct": 12.8,
   "method": "Roberts et al. (2021) Table 4 mean difference from the average Air Force woman under 30, sign reversed so faster is positive; 95% CI from the paper."
  },
  {
   "timeOnHormones": "Year 1-2",
   "estimate": 64,
   "ciLow": 26,
   "ciHigh": 101,
   "ciLevel": 0.95,
   "unit": "seconds faster than the average Air Force woman over 1.5 miles",
   "transWomenSeconds": 791,
   "averageWomanSeconds": 855,
   "speedAdvantagePct": 8.1,
   "method": "Roberts et al. (2021) Table 4 mean difference from the average Air Force woman under 30, sign reversed so faster is positive; 95% CI from the paper."
  },
  {
   "timeOnHormones": "Year 2-2.5",
   "estimate": 90,
   "ciLow": 10,
   "ciHigh": 169,
   "ciLevel": 0.95,
   "unit": "seconds faster than the average Air Force woman over 1.5 miles",
   "transWomenSeconds": 765,
   "averageWomanSeconds": 855,
   "speedAdvantagePct": 11.8,
   "method": "Roberts et al. (2021) Table 4 mean difference from the average Air Force woman under 30, sign reversed so faster is positive; 95% CI from the paper."
  }
 ],
 "allMeasures": [
  {
   "measure": "pushups",
   "timeOnHormones": "Year 0 (before)",
   "transWomenMean": 47.3,
   "averageWoman": 32.5,
   "diffVsAverageWoman": 14.8,
   "diffCiLow": 12.1,
   "diffCiHigh": 17.4,
   "advantagePct": 45.5,
   "paperConventionPct": 31.3,
   "significantAt95": true
  },
  {
   "measure": "pushups",
   "timeOnHormones": "Year 0-1",
   "transWomenMean": 44.6,
   "averageWoman": 32.5,
   "diffVsAverageWoman": 12.1,
   "diffCiLow": 9.3,
   "diffCiHigh": 14.8,
   "advantagePct": 37.2,
   "paperConventionPct": 27.1,
   "significantAt95": true
  },
  {
   "measure": "pushups",
   "timeOnHormones": "Year 1-2",
   "transWomenMean": 43.2,
   "averageWoman": 32.5,
   "diffVsAverageWoman": 10.7,
   "diffCiLow": 6.8,
   "diffCiHigh": 14.5,
   "advantagePct": 32.9,
   "paperConventionPct": 24.8,
   "significantAt95": true
  },
  {
   "measure": "pushups",
   "timeOnHormones": "Year 2-2.5",
   "transWomenMean": 34.6,
   "averageWoman": 32.5,
   "diffVsAverageWoman": 2.1,
   "diffCiLow": -6.4,
   "diffCiHigh": 10.5,
   "advantagePct": 6.5,
   "paperConventionPct": 6.1,
   "significantAt95": false
  },
  {
   "measure": "situps",
   "timeOnHormones": "Year 0 (before)",
   "transWomenMean": 53.5,
   "averageWoman": 45.6,
   "diffVsAverageWoman": 7.9,
   "diffCiLow": 5.7,
   "diffCiHigh": 10,
   "advantagePct": 17.3,
   "paperConventionPct": 14.8,
   "significantAt95": true
  },
  {
   "measure": "situps",
   "timeOnHormones": "Year 0-1",
   "transWomenMean": 54.1,
   "averageWoman": 45.6,
   "diffVsAverageWoman": 8.5,
   "diffCiLow": 6.3,
   "diffCiHigh": 10.7,
   "advantagePct": 18.6,
   "paperConventionPct": 15.7,
   "significantAt95": true
  },
  {
   "measure": "situps",
   "timeOnHormones": "Year 1-2",
   "transWomenMean": 51.8,
   "averageWoman": 45.6,
   "diffVsAverageWoman": 6.2,
   "diffCiLow": 3,
   "diffCiHigh": 9.3,
   "advantagePct": 13.6,
   "paperConventionPct": 12,
   "significantAt95": true
  },
  {
   "measure": "situps",
   "timeOnHormones": "Year 2-2.5",
   "transWomenMean": 44.8,
   "averageWoman": 45.6,
   "diffVsAverageWoman": -0.9,
   "diffCiLow": -8.4,
   "diffCiHigh": 6.7,
   "advantagePct": -1.8,
   "paperConventionPct": -2,
   "significantAt95": false
  },
  {
   "measure": "run",
   "timeOnHormones": "Year 0 (before)",
   "transWomenMean": 708,
   "averageWoman": 855,
   "diffVsAverageWoman": -147,
   "diffCiLow": -173,
   "diffCiHigh": -121,
   "advantagePct": 20.8,
   "paperConventionPct": 20.8,
   "significantAt95": true
  },
  {
   "measure": "run",
   "timeOnHormones": "Year 0-1",
   "transWomenMean": 758,
   "averageWoman": 855,
   "diffVsAverageWoman": -97,
   "diffCiLow": -124,
   "diffCiHigh": -70,
   "advantagePct": 12.8,
   "paperConventionPct": 12.8,
   "significantAt95": true
  },
  {
   "measure": "run",
   "timeOnHormones": "Year 1-2",
   "transWomenMean": 791,
   "averageWoman": 855,
   "diffVsAverageWoman": -64,
   "diffCiLow": -101,
   "diffCiHigh": -26,
   "advantagePct": 8.1,
   "paperConventionPct": 8.1,
   "significantAt95": true
  },
  {
   "measure": "run",
   "timeOnHormones": "Year 2-2.5",
   "transWomenMean": 765,
   "averageWoman": 855,
   "diffVsAverageWoman": -90,
   "diffCiLow": -169,
   "diffCiHigh": -10,
   "advantagePct": 11.8,
   "paperConventionPct": 11.8,
   "significantAt95": true
  }
 ],
 "averageWoman": {
  "pushups": 32.5,
  "situps": 45.6,
  "runSeconds": 855
 }
}